This paper analyses the flow of MHD Casson nanofluid in a steady-state on a linearly stretched sheet on a 2D boundary layer with radiation and heat generation. Parametric study of heat generation, radiation, suction/injection, Casson fluid flow parameter, Lewis number, thermophoresis, and Prandtl number have been carried out. The nonlinear coupled partial differential equations are changed into a nonlinear coupled ordinary differential equation by similarity transformations and are solved with the 4 th order Runge-Kutta method with the shooting technique. From the current investigation it is been recorded that, magnifying heat generation and radiation parameters amplify the thermal process and diminishes the concentration diffusion. Amplifying heat generation led to the decelerating of local Nusselt number. To conclude, the novelty of current research work is to simplify the earlier works by considering heat source, Ohmic heating, thermophoresis, Brownian and radiation effects into the corresponding governing equations. Comparative study has been presented with the previous outcomes and observed to be in good understanding with the previously presented results.