This article reports a case of a middle-aged man who was admitted to the hospital for sudden upper abdominal pain several hours later. After being given the painkiller Compound Diclofenac Sodium in the outpatient clinic, the patient developed systemic itching, redness, and rash. Acute pancreatitis was diagnosed after admission. During treatment, the patient was found to have allergic reactions to multiple drugs. This case is rare. This article uses case reports to improve clinical pharmacists and clinicians understanding of multi-drug allergies, and provides certain reference for solving the safety and effectiveness of medication in patients with multi-drug allergies.