This paper proposes a system architecture for deploying AI-driven interactive systems within the context of a Cyber-Physical-Social System framework, specifically designed for applications in the emerging Metaverse, applicable to a plethora of domains. The proposed architecture integrates advanced technologies to facilitate immersive user experiences and intelligent system interactions based on user actions and realtime data inputs from the real and the digital world(s), digital twins, artificial agents and elements. The integration of the proposed architecture components aim to support sophisticated interactions between physical, digital entities, and humans within the Metaverse. The paper presents the theoretical underpinnings and system description of the proposed architecture, contributing to future developments in Metaverse systems and technologies. This article has been accepted for publication in IEEE International Symposium on Emerging Metaverse (ISEMV 2024). This is the author's version which has not been fully edited and content may change prior to final publication. Citation information: L. Nisiotis, "A System Architecture for AI-Driven Interactive Systems Within a CPSS Framework for Metaverse Applications," 2024 IEEE International Symposium on Emerging Metaverse (ISEMV), Bellevue, WA, USA, 2024, pp. 9-12, doi: 10.1109/ISEMV63338.2024.00016.