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Ta-Ag Coatings on TC4: A Strategy to Leverage Bioelectric Microenvironments for Enhanced Antibacterial Activity
  • +10
  • Yuxin Gong,
  • Guangbin Zhao,
  • Xiang Liang,
  • Ming Yu,
  • Le Bai,
  • Xin Yang,
  • Chonghao Yao,
  • Hao Cui,
  • Linyang Xie,
  • Bingheng Lu,
  • Junbo Tu,
  • Sijia Na,
  • Fangfang Xu
Yuxin Gong
Xi'an Jiaotong University
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Guangbin Zhao
Xi'an Jiaotong University
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Xiang Liang
Xi'an Jiaotong University
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Ming Yu
Xi'an Jiaotong University
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Le Bai
Xi'an Jiaotong University
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Xin Yang
Xi'an Jiaotong University
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Chonghao Yao
Xi'an Jiaotong University
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Hao Cui
Xi'an Jiaotong University
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Linyang Xie
Xi'an Jiaotong University
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Bingheng Lu
Xi'an Jiaotong University
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Junbo Tu
Xi'an Jiaotong University
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Sijia Na
Xi'an Jiaotong University
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Fangfang Xu
Xi'an Jiaotong University

Corresponding Author:xff@mail.xjtu.edu.cn

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Abstract

Dental implant- related infections are serious complications after surgery that can results in loosening or even complete loss of the implant. Although endogenous electric fields (EEF) play an integral role in the human body, current methods involving external electrical stimulation are invasive and not suitable for clinical application. In this study, we using DC magnetron sputtering, investigates the effects of tantalum silver (Ta-Ag) coatings on titanium alloy (TC4) surfaces, focusing on their potential to influnce EEF that enhances antibacterial activity In this design, Ta-Ag configuration effectively increased the surface potential difference of TC4, and furthermore, promoting Ta/Ag ions release and reducing bacterial adhesion. The study concludes that the Ta-Ag coating, particularly the TC4-Ta/Ag implant, promotes a stable EEF, enhancing the long-term antibacterial and osteogenic properties of implants. This work provides a promising strategy for developing advanced implant materials with improved clinical efficacy.
29 Oct 2024Submitted to Biotechnology Journal
30 Oct 2024Review(s) Completed, Editorial Evaluation Pending
30 Oct 2024Submission Checks Completed
30 Oct 2024Assigned to Editor
04 Nov 2024Reviewer(s) Assigned