This study aims to elucidate the ideal training volume for maximizing muscle hypertrophy in advanced strength athletes through a systematic review and meta-analysis of the extant literature with high scientific hierarchy. Emphasis is placed on discerning the optimal number of weekly sets (4-10) and repetition ranges pertinent to specific muscle groups, contextualized within their fiber-type compositions. Recent empirical evidence advocates for training protocols that employ higher RPE (Rate of Perceived Exertion) alongside lower overall volumes to facilitate superior hypertrophic adaptations (Beardsley & Schoenfeld, 2019; Schoenfeld et al., 2017). This paper synthesizes contemporary findings, offering evidence-based guidelines tailored for advanced strength athletes and contributing to the discourse surrounding effective training methodologies. Keywords: Hypertrophy, training volume, strength athletes, systematic review, meta-analysis, RPE.