Key Clinical Message:

We report a rare case of psoriasis which developed “Rhupus” overlap disease. Diagnosing multiple connective tissue disease is challenging as most of them mimics similar symptoms. The diagnostic dilemma & treatment strategy we faced will provide guidance towards such patient dealings. Further routine follow up is needed for good prognosis.Keywords : Rhupus syndrome, Rheumatoid arthritis, Systemic lupus erythematosus (SLE), Psoriatic arthritis (PsA), Autoimmune overlap syndrome, Case report