CONCLUSION:
Necrobiosis lipoidica and morphea are two distinct skin conditions that share some similarities but also have notable differences. In rare cases, patients have been found to have both NL and morphea concurrently, suggesting a potential overlap in their underlying pathophysiological mechanisms. Both diseases are marked by distinct patterns of inflammation and collagen abnormalities, with NL featuring necrobiotic collagen and morphea exhibiting collagen overproduction leading to sclerosis. Additionally, female predominance and similar treatment approaches including immunomodulators and phototherapy, further highlights their shared pathophysiological mechanisms involving immune system dysregulation.
Table 1 : NL & associated cutaneous comorbidities