CONCLUSION:
Necrobiosis lipoidica and morphea are two distinct skin conditions that
share some similarities but also have notable differences. In rare
cases, patients have been found to have both NL and morphea
concurrently, suggesting a potential overlap in their underlying
pathophysiological mechanisms. Both diseases are marked by distinct
patterns of inflammation and collagen abnormalities, with NL featuring
necrobiotic collagen and morphea exhibiting collagen overproduction
leading to sclerosis. Additionally, female predominance and similar
treatment approaches including immunomodulators and phototherapy,
further highlights their shared pathophysiological mechanisms involving
immune system dysregulation.
Table 1 : NL & associated cutaneous comorbidities