The Healthcare Integrated Research Database (HIRD) is a real-world data source for health-related research. Data elements of the HIRD, including sourcing, timeliness, and validity, demographic and healthcare-related characteristics of individuals in the HIRD, and aspects of the HIRD relevant to real-world evidence generation, are described. The HIRD includes health insurance claims and other health-related information for individuals enrolled in health insurance plans offered or managed by Elevance Health and has been utilized for research for almost two decades. Individuals in the HIRD reside throughout the United States. Data in the HIRD are available since January 1, 2006, and are updated monthly. As of July 31, 2024, the researchable population of the HIRD included over 91 million individuals with medical benefits, and over 24 million individuals were actively enrolled. The median age of individuals in the HIRD is 36 years (interquartile range, IQR: 22, 54) and 50% of individuals in the HIRD are female. The median duration of continuous enrollment in the HIRD is 2.0 years (IQR: 0.8, 4.7). For those actively enrolled, the median duration of continuous enrollment is 3.8 years (IQR: 1.7, 8.3). Other important characteristics of the HIRD include the ability to trace data back to their source, to support both deterministic and probabilistic linkage with external data sources, and to link family members within health plans. The HIRD has been a trusted resource to generate real-world evidence for a variety of health-related research, including regulatory required safety studies, comparative effectiveness studies, and health outcomes and economics research.