Aims: The incidence of cognitive disorders is rising. Phytochemical compounds have had some success in improving cognitive outcomes in preclinical studies. A limited number of these have progressed to clinical trials. However, the evidence in support of phytochemical use in (1) improving cognition in healthy individuals or (2) as prophylaxis and treatment against the cognitive sequelae of neuropathogies, remains to be demonstrated. We sought to systematically evaluate the current evidence base surrounding the impact of phytochemical agents on cognitive function in healthy individuals, with a view to exploring their clinical application. Methods: A systematic search of Web of Science, PubMed, PsycNET, and AYUSH Research Portal was performed for double-and single-blind randomized controlled trials assessing the efficacy of Curcuma longa, Bacopa monniera, Ocimum sanctum, Camellia sinesis, Centella asiatica, Ganoderma lingzhi, and Rosmarinus officinalis, on cognitive function. Results: Seven studies from the initial 144 search results, were included, comprising of 416 participants examining the impact of either Bacopa monniera, Ocimum sanctum or Camellia sinesis. Meta-analysis revealed no benefit of Bacopa monniera or Camellia sinesis on processing speed, attention, working memory, language, psychomotor function or overall cognitive performance. Ocimum sanctum improved reaction times on an executive function task. Conclusion: Collectively, no beneficial effects were seen in healthy populations. The limited number of trials, methodological issues and unclear risk of bias casts doubt on the validity and extrapolation of these findings. More methodologically robust trials are recommended of longer duration to investigate the efficacy of phytochemicals for cognition.