Hyers-Ulam (HU) stability for systems of incommensurate Fractional Differential Equations (FDEs) is studied. The existence and uniqueness of the mild solutions are obtained in the space of discontinuous functions. The related analysis for Laplace transforms is stated and it is used for HU stability. It is shown that the HU stability is equivalent to the convergence of the perturbed system toward the original system when the error of the perturbed source vanishes. Numerical methods based on HU stability are proposed. The analysis is investigated within some examples.