Key Clinical Message:
Thrombotic thrombocytopenic purpura (TTP) can present with serious complications like pancreatitis and myocardial infarction. Early recognition and treatment with plasma exchange are critical to improving patient outcomes.
Abstract:
Thrombotic thrombocytopenic purpura (TTP) is a rare disease with a mortality rate of 90% if not treated promptly. Due to limited clinical experience and sometimes atypical presentation, early detection of TTP is not always easy. The pathophysiological mechanisms underlying TTP can accelerate thrombus formation and vascular occlusion, potentially leading to ischemic damage in various organs, including the heart and pancreas. Considering that the complications caused by these disorders can be life-threatening, the simultaneous manifestation of acute pancreatitis (AP), TTP, and heart damage in the patient may cause a significant risk of mortality if not treated in time and adequately. We report a case involving a 43-year-old patient who presented with symptoms of myocardial infarction (MI) and acute pancreatitis (AP) secondary to thrombotic thrombocytopenic purpura (TTP). The patient was diagnosed based on clinical manifestations, laboratory findings, and imaging studies. Immediate intervention included plasma exchange and supportive care, which led to the stabilization of the patient’s condition. This case emphasizes the importance of increased vigilance for AP symptoms and cardiac complications in patients with TTP presenting with atypical symptoms. Early diagnosis and prompt treatment are critical in reducing the risk of mortality associated with these severe complications.
Keywords: Acute Pancreatitis(AP); Thrombotic Thrombocytopenic Purpura(TTP); Myocardial Infarction(MI)