Key Clinical Message:
Thrombotic thrombocytopenic purpura (TTP) can present with serious
complications like pancreatitis and myocardial infarction. Early
recognition and treatment with plasma exchange are critical to improving
patient outcomes.
Abstract:
Thrombotic thrombocytopenic purpura (TTP) is a rare disease with a
mortality rate of 90% if not treated promptly. Due to limited clinical
experience and sometimes atypical presentation, early detection of TTP
is not always easy. The pathophysiological mechanisms underlying TTP can
accelerate thrombus formation and vascular occlusion, potentially
leading to ischemic damage in various organs, including the heart and
pancreas. Considering that the complications caused by these disorders
can be life-threatening, the simultaneous manifestation of acute
pancreatitis (AP), TTP, and heart damage in the patient may cause a
significant risk of mortality if not treated in time and adequately. We
report a case involving a 43-year-old patient who presented with
symptoms of myocardial infarction (MI) and acute pancreatitis (AP)
secondary to thrombotic thrombocytopenic purpura (TTP). The patient was
diagnosed based on clinical manifestations, laboratory findings, and
imaging studies. Immediate intervention included plasma exchange and
supportive care, which led to the stabilization of the patient’s
condition. This case emphasizes the importance of increased vigilance
for AP symptoms and cardiac complications in patients with TTP
presenting with atypical symptoms. Early diagnosis and prompt treatment
are critical in reducing the risk of mortality associated with these
severe complications.
Keywords: Acute Pancreatitis(AP); Thrombotic Thrombocytopenic
Purpura(TTP); Myocardial Infarction(MI)