Impact of high indoor CO2 exposure has not been studied in detail in an academic occupational setting, especially in Qatar, albeit the existence of a clear cause and effect between high CO2 concentration and declining global health. In comparison to the outdoor CO2 concentration, the average indoor CO2 concentration in occupational environment (offices and schools), typically ranges from 600 to 1,000 ppm. This indoor concentration can exceed 2,000 ppm with increase in room occupancies and reduction in building ventilation rates, and can result in a multitude of public health issues. In here we studied the variability in CO2 concentration and try to model its change as a function of population density mimicking the global changes in climate and population. Results indicated that in places where population density crosses a threshold value, the indoor CO2 concentration can increase as much as ~9 ppm/min and can have enormous health impact even in short durations of acute exposure.