Objectives: The objective of this study was to assess cognitive impairment in patients with pre-frontal low-grade gliomas (LGG) involving the Superior Longitudinal Fasciculus (SLF). Methodology: The current study documented cognitive impairment using the battery of tests temporarily licensed from The Many Brains Project (TMB) in patients who underwent surgery for pre-frontal low-grade glioma (LGG) with radiological evidence of involvement of the Superior Longitudinal Fasciculus (SLF). Results: Post-operative neuropsychological evaluations in patients with SLF lesions revealed significantly reduced cognitive performance compared to healthy participants. These deficits were evident in tests such as Simple Reaction Time, Visual Patterns, Digit Symbol Substitution, Digit Span, Attention tasks, and the Trail Making Test. Conclusion: Functional domains like attention, working memory, and executive function may be affected in the patients by both the tumor and neurosurgical intervention. Based on these results, we recommend using Reaction Time, Digit Substitution Test (DST), Multiple Object Tracking (MOT), and Trail Making Test (TMT) as practical cognitive evaluation tools, complementing traditional Intraoperative Neurophysiological techniques. Significance: Cognitive assessment is crucial in LGG patients, particularly when SLF is affected, to monitor deficits in attention, working memory, and executive function.