4.3. Limitations
This study had a few limitations. First, the at-risk group was primarily
chosen to have at least one first-degree relative with a history of
mania. However, the assessment of mania for first-degree relatives was
based on self- or other-report, and not confirmed by a structured
interview. Second, as discussed, this ABCD study is collecting
prospective data and the children’s report on their recent traumatic
experiences might be underestimated. Third, as this study did not
explore all potential diagnoses and used symptoms rather than diagnostic
criteria, the overlap between manic and ADHD symptoms warrants caution
when interpreting the results.