An equitable and accessible informed consent process is needed to support people with vision and hearing disability to make independent health decisions. Research and health service providers need to make deliberate and intentional efforts to ensure that communications and information provision meet the needs of the individual. Identification and evaluation of strategies to enhance agency during informed consent procedures for people with sensory impairment is needed. This systematic review will synthesize evidence on the most effective strategies to improve information accessibility and shared decision making for people with vision and hearing impairment in informed consent practice. In doing so, this review will produce recommendations for inclusive practice and guide future work on intervention development and primary research in improving equity and inclusion in health care and clinical research.