Corneal injury is common in ophthalmology, with mild cases affecting the patient's vision and severe cases leading to permanent blindness. The current common treatment method in clinical practice is transplantation surgery supplemented by drug therapy. However, surgical sutures have a series of defects and cannot perfectly meet the needs of wound healing. The use of medical tissue adhesive effectively compensates for its shortcomings and has gradually become an alternative material to sutures. With the development of biomedical materials in recent years, modern ophthalmic tissue adhesive is no longer limited to wound closure but also has effects such as inhibiting vascular regeneration and antimicrobial properties. In addition, the integration of tissue adhesive with other disciplines has shown promising effects in drug delivery, ophthalmic disease diagnosis, and other areas. This article introduces common medical tissue adhesives and briefly describes their applications in ophthalmology, hoping that readers can be inspired by this article on tissue adhesives or clinical ophthalmic treatment.