Assessment of how well Nature based Solutions (NbS) can offset climate change is vital for mitigation and adaptation planning, but has rarely been done. Therefore, this study aimed to assess the role of NbS and vegetation health in mitigating the effects of climate change in River Isiukhu basin using Normalized Difference Vegetation Index (NDVI) and Normalized Difference Bare Soil Index (NDBSI). NDVI and NDBSI were derived from Google Earth Engine and ArcGIS Pro 3.2. Precipitation and temperature data was collected from Climate Hazards Group InfraRed Precipitation with Station data (CHIRPS) and TERRACLIMATE respectively. The relationship between remote sensing indices (NDBSI/NDVI) and temperature/precipitation were explored using Pearson correlation. Three major NbS projects were noted in the region. NDVI increased by 35% between 1990 to 2023. The increases were noted between 1990-2013 while declines were noted between 2013-2023. NDBSI decreased between 1990-2013 and increased between 2013-2023. In terms of climate variability, the overall precipitation increased by 22.7% (427.3 mm) between 1990 -2023. The mean temperature increased by 7.43% (1.5˚C) between 1990-2023. There was a positive relationship between precipitation and NDVI (r = 0.5549) and a negative correlation between precipitation and NDBSI (r = -0.139). Temperature was both positively correlated with NDVI (r = 0.8237) and NDBSI (r = 0.1916). Therefore, vegetation health and cover greatly controlled the climatic conditions of River Isiukhu basin. This study prioritises the adoption of NbS for climate change mitigation in River Isiukhu Basin. The study findings can be used as a reference for measuring the effectiveness of NbS in mitigating climate change in the world.