Background and Objective: The purpose of the study is to determine the degree to which community-wide activities in the Pomona Youth and Family Master Plan (PYFMP) might have influenced youth ATOD use changes in Pomona and in comparison to US jurisdictions. M ethods: An integrated framework encompassing social cognitive theory and the risk and protective factor approach guides the study. Same group and independent group comparisons within and across school grades, intervention years and jurisdictions were conducted in a quasi-experimental design. The baseline (2005-06) and follow up (2009-10) samples were as follows: Pomona sample was 3,967(2005-06) and 2,693(2009-10);and for US, the samples were 122,243(2005-06) and 101,141(2009-10). Results: Within the five years under study, overall youth ATOD use trends in Pomona, particularly in comparison with US trends, showed a slow but clear shift. Discussion and Conclusion: The findings suggest that community-wide interventions in the PYFMP might have shifted individual ATOD use among Pomona Youth. The slow pace of change calls for studies to examine the following factors which influence youth ATOD use that were not investigated in this study: specific community-level factors that might have influenced individual youth ATOD use; the effect underlying socio-economic and resource factors on youth ATOD use and the role of micro level factors and interventions.