Lithium metal is regarded as the most promising anode for next generation high-energy-density batteries. However, it still suffers from the problems associated with the uncontrollable dendrite growth and infinite volume expansion. Herein, a flexible and insulative polyethylene mesh (PM) has been used to partition the electrochemical reaction area, enhancing the uniformity of Li deposition/dissociation behaviors within localized regions. On the one hand, the insulating mesh can restrict the transport direction of Li+, mitigating “hotspots” induced by Li-ions agglomeration and thereby preventing dendrites formation. On the other hand, after Li deposited in segmented areas, the failure within a single mesh will not affect the performance of the entire electrode, thus improving the long-term stability of the electrode. Nevertheless, the mesh number as well as the thickness of the PM have significant influence on Li deposition/dissolution behaviors. As a result, the PM-40 with a thickness of 0.1 mm demonstrated the best regulation effects: in Cu||Li half-type cell, the PM-40 exhibited excellent cycling stability with an average Coulombic efficiency (CE) of 97.3%. When paired with LiFePO4 cathodes, the PM-40 demonstrated superior long-term cycling stability over 700 cycles with 98.87% capacity retention at 1C. This work effectively improves the uniformity of Li plating/stripping behaviors and electrochemical performance through a highly cost-effective method. Meanwhile, this work paves the way for realizing high-performance anode-free lithium metal batteries (LMBs) through the strategy of confined Li reaction.