Figure 6. BET-bromodomain inhibitor JQ-1 inhibits human mast cell activation to a similar extent as butyrate. (A) Primary human mast cells were treated with increasing concentrations of JQ-1 for 24 h, primed with IgE and cross-linked with anti-IgE. Percentage of mast cell degranulation (as measured by beta-hexosaminidase release) after IgE-mediated activation using anti-IgE stimulation in primary human mast cells treated with increasing concentrations of JQ-1. (B)