javascript:void(0)Butyrate preferentially suppresses super-enhancers and their associated genes
Because super-enhancers can be extensively acetylated and have been reported as preferential targets of HDAC inhibitors 36,37, we next investigated H3K27Ac dynamics at super-enhancers and transcriptional changes of their target genes. From two biological replicates, 608 reproducible super-enhancers were identified that were linked to 588 unique associated genes in untreated primary human mast cells (Fig. 5A). These genes were strongly enriched for immune effector cell processes, such as cell activation, exocytosis and secretion (Fig. 5B). These included super-enhancers associated with CD9, LAIR1, COTL1 and LAT, which are known regulators of mast cell mediator secretion (Fig. 5C), as well as other mast cell-associated genes such as KIT, MS4A2 and LYN (Supplementary Table 2).