not-yet-known not-yet-known not-yet-known unknown Epigenetic explanation for butyrate-induced downregulation of gene expression. The proportion of downregulated genes with significant hypo-acetylated TSS (purple), TSS and SE (green), SE (yellow) and non-significant reduced acetylation (pink). Differential enrichment was calculated using DESeq2 (fold change > 2 and adjusted P value < 0.05).