Abstract

not-yet-known not-yet-known not-yet-known unknown Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the intestines characterized by a progressive and unpredictable course, and colorectal cancer (CRC), a malignant tumor of the colon or rectum, is a malignant disease that seriously affects human health. The risk of colitis-associated cancer (CAC) is high in patients with IBD, and CRC is one of the most serious consequences for patients with IBD. Cell death is a fundamental physiological process in all living organisms, and it includes apoptosis, necroptosis, pyroptosis, autophagy, ferroptosis, and cuproptosis. Regulatory cell death (RCD), a form of cell death that can be regulated by a variety of biomolecules, plays an important role in maintaining physiological homeostasis in the body, resistance to pathogen attack, and a range of pathological states, such as inflammation and cancers. There is growing evidence that different types of RCD are involved not only in the pathogenesis of IBD, CRC, and CAC but also in the therapeutic process. The present review will provide ideas for further exploration of RCD affecting IBD, CRC, and CAC by summarizing the possible mechanisms of the involvement of different types of RCD in IBD, CRC, and CAC. Additionally, this article will discuss recent advancements in pharmacotherapy.