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Coexisting Lung Cancer and Pulmonary Tuberculosis: A Comprehensive
Review from Incidence to Management
- Wendi Zhou,
- Hongxu Lu,
- Jiamin Lin,
- Jialou Zhu,
- Jizhen Liang,
- Yalin Xie,
- Jinxing Hu,
- Ning Su
Wendi Zhou
First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease
Author ProfileHongxu Lu
First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease
Author ProfileJiamin Lin
First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease
Author ProfileJialou Zhu
First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease
Author ProfileYalin Xie
First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease
Author ProfileJinxing Hu
First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease
Corresponding Author:hujinxing@gzhmu.edu.cn
Author ProfileNing Su
First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease
Author ProfileAbstract
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Background: Globally, infections account for 10% of new cancer
cases, and cancer can compromise the immune system, increasing the risk
of infections. With advances in cancer treatment, widespread use of
immunotherapy, and prolonged survival of cancer patients, the
coexistence of tuberculosis (TB) and cancer is becoming increasingly
common in clinical settings. Aim: This review aims to explore
the interaction between tuberculosis (TB) and tumors, particularly lung
cancer (LC), and to identify appropriate clinical management approaches.
Results: LC patients with a history of TB have higher adjusted
risk ratios for both all-cause and cancer-specific three-year mortality
compared to those without a history of TB. TB may elevate the risk of
developing tumors through mechanisms such as chronic inflammation,
altered immune responses, and DNA damage. Conversely, cancer patients,
whether due to the disease itself or immune dysfunction caused by
anti-tumor treatments, may be more susceptible to TB. The coexistence of
TB and tumors presents significant challenges in clinical management,
making the development of treatment strategies and quality-of-life
improvements crucial. Conclusion: There is a close relationship
between TB and cancer, with TB potentially serving as a risk factor for
cancer, and cancer influencing susceptibility to TB. Effective clinical
management is essential to enhance treatment strategies and improve the
quality of life for patients with both TB and cancer.19 Aug 2024Submitted to Cancer Reports 29 Aug 2024Submission Checks Completed
29 Aug 2024Assigned to Editor
29 Aug 2024Review(s) Completed, Editorial Evaluation Pending
02 Sep 2024Reviewer(s) Assigned