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not-yet-known not-yet-known not-yet-known unknown Coexisting Lung Cancer and Pulmonary Tuberculosis: A Comprehensive Review from Incidence to Management
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  • Wendi Zhou,
  • Hongxu Lu,
  • Jiamin Lin,
  • Jialou Zhu,
  • Jizhen Liang,
  • Yalin Xie,
  • Jinxing Hu,
  • Ning Su
Wendi Zhou
First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease
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Hongxu Lu
First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease
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Jiamin Lin
First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease
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Jialou Zhu
First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease
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Jizhen Liang
Guangzhou Red Cross Hospital
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Yalin Xie
First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease
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Jinxing Hu
First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease

Corresponding Author:hujinxing@gzhmu.edu.cn

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Ning Su
First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease
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Abstract

not-yet-known not-yet-known not-yet-known unknown Background: Globally, infections account for 10% of new cancer cases, and cancer can compromise the immune system, increasing the risk of infections. With advances in cancer treatment, widespread use of immunotherapy, and prolonged survival of cancer patients, the coexistence of tuberculosis (TB) and cancer is becoming increasingly common in clinical settings. Aim: This review aims to explore the interaction between tuberculosis (TB) and tumors, particularly lung cancer (LC), and to identify appropriate clinical management approaches. Results: LC patients with a history of TB have higher adjusted risk ratios for both all-cause and cancer-specific three-year mortality compared to those without a history of TB. TB may elevate the risk of developing tumors through mechanisms such as chronic inflammation, altered immune responses, and DNA damage. Conversely, cancer patients, whether due to the disease itself or immune dysfunction caused by anti-tumor treatments, may be more susceptible to TB. The coexistence of TB and tumors presents significant challenges in clinical management, making the development of treatment strategies and quality-of-life improvements crucial. Conclusion: There is a close relationship between TB and cancer, with TB potentially serving as a risk factor for cancer, and cancer influencing susceptibility to TB. Effective clinical management is essential to enhance treatment strategies and improve the quality of life for patients with both TB and cancer.
19 Aug 2024Submitted to Cancer Reports
29 Aug 2024Submission Checks Completed
29 Aug 2024Assigned to Editor
29 Aug 2024Review(s) Completed, Editorial Evaluation Pending
02 Sep 2024Reviewer(s) Assigned