AbstractOsseous metaplasia (OM), defined as the formation of mature bone in non-osseous tissue, is a rare finding in colorectal adenocarcinoma, with a reported incidence of 0.15–0.4% and only one previously documented case from Ethiopia. We report a 54-year-old Ethiopian man with known colonic adenocarcinoma who presented with worsening fatigue, syncope, and vomiting over five days, along with a palpable right lower quadrant abdominal mass. Contrast-enhanced CT revealed circumferential asymmetric thickening of the cecum and ascending colon with small hyperdense calcified foci. Intraoperative findings showed a perforated cecal mass with minimal peritoneal contamination. Histopathologic examination demonstrated invasive adenocarcinoma with irregular glands and pleomorphic cells infiltrating the stroma, accompanied by benign trabecular bone formation with osteoblastic rimming, confirming osseous metaplasia. Although imaging may raise suspicion through the presence of calcifications, histopathology is required for definitive diagnosis. This case represents the first report of colonic adenocarcinoma with osseous metaplasia presenting with tumor perforation and emphasizes the importance of clinicoradiologic-pathologic correlation.Keywords : Adenocarcinoma; colon; osseous metaplasia; perforation; case report

AbstractUterine lipoleiomyoma is a rare subtype of leiomyoma composed of bundles of smooth muscle and fat. The majority of cases tend to be small and are usually diagnosed incidentally in obese postmenopausal women. Hereby we presented a large uterine lipoleiomyoma in a premenopausal woman presented with abnormal uterine bleeding. This case report highlights clinicoradiopathologic features of uterine lipoleiomyoma and briefly reviews the existing literature.

A document by Musie Negasi. Click on the document to view its contents.

AbstractEthmocephaly is the most severe form of holoprosencephaly, which results from incomplete cleavage of the forebrain during embryogenesis. It is incompatible with life. Here we reported a case of ethmocephaly in a clomiphene citrate induced pregnancy. Hereby we reported a 32-year-old woman, gravida 6, at a gestational age of 23 weeks, presented for routine antenatal care. Up on ultrasound scanning, there were brain abnormalities, like a single dilated ventricle, absent falx cerebri, and facial profile abnormalities like proboscis. After delivery, on physical examination of the newborn, we found ocular hypotelorism, a 5 cm midline proboscis located above the eyes, and absent nasal structures. The mother had used clomiphene for two cycles prior to conception, with no other notable medical history. In conclusion, ethmocephaly is a severe and typically fatal condition requiring early prenatal detection for better planning. While there is no clear link between clomiphene use and holoprosencephaly, further research is needed to explore any potential risks and guide clinical practice.Keywords:  Ethmocephaly, holoprosencephaly, hypotelorism, proboscis, Clomiphene citrate

AbstractFibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disorder characterized by congenital malformation of the great toe and heterotopic ossification in the connective tissue of muscles, tendons, ligaments, fascia, and aponeurosis. It has an incidence of 1 in 2 million, with fewer than 700 reported cases worldwide to date. The aim of this case report is to highlight clinical features of FOP to facilitate early diagnosis and minimize the impact of its delayed diagnosis. We report a case of a 42-year-old man who presented with multiple soft tissue swellings of 30 years duration, later leading to an inability to move. Physical examination findings included firm to hard tender masses over bilateral forearms, left arm, anterior and posterior chest, bilateral hips, and bilateral distal thighs, along with bilateral subtle hallux valgus. He had been visiting nearby health centers for the past 30 years, but a diagnosis was not made until his current visit. Based on the clinical finding of hallux valgus and radiologic evidence of extraskeletal ossifications, a diagnosis of FOP was made. He is currently on analgesics and receives a short course of corticosteroids during flare-ups. Although rare, primary care physicians should consider FOP in patients presenting with soft tissue ossifications to minimize suffering and disability due to delayed diagnosis. While the confirmatory diagnostic modality for FOP is genetic test, for low-income countries where the genetic test is not easily accessible, clinical diagnosis should be considered to prevent unnecessary disease progression.Key words : Fibrodysplasia ossificans; Heterotopic ossification; Stoneman disease; case report

A Case of Breast Filariasis Diagnosed on Fine Needle Aspiration CytologyBirhanu Kassie Reta1 , Biruk Legesse Tadesse2, Eleni Getahun Kebede3, Atsede Birhanu Worku3, Michael Teklehaimanot Abera4Aksum University College of Health Science, Department of Pathology, Aksum, EthiopiaArsi university College of health Science, Department of Pathology, Asella, EthiopiaWoldia University, Woldia, EthiopiaAddis Ababa University, College of Health Sciences, Addis Ababa UniversityAuthors contact Address1. Birhanu Kassie Reta, MD,birexkassie24@gmail.com (ORCHID ID: 0009-0001-1897-9072)2.. Biruk Legesse Tadesse, MD, brooktade12@gmail.com(ORCHID ID: 0000-0001-6889-5320)3. Eleni Getahun Kebede, MD, getahuneleni@gmail.com (ORCHID ID: 0009-0004-8676-1691)4. Atsede Birhanu Worku, MD, atsedemaryamfabb@gmail.com( ORCHID ID: 0009-0006-0050-9634)5. Michael Teklehaimanot Abera, MD michael.teklehaimanot@aau.edu.et, th.miki8441@gmail.com