Conclusion:
This case report highlights the rare co-occurrence of Wilson’s disease (WD) and systemic lupus erythematosus (SLE). Both diseases can affect multiple organs, making diagnosis challenging. Furthermore, the use of penicillamine, a common treatment for WD, can worsen SLE. This necessitates other approaches, such as zinc supplementation alone, which may be insufficient for long-term management in patients with coexisting WD and SLE. Therefore, long-term follow-up and more studies are needed to see the response in such patients.