Title: P2X7 receptor antagonism suppresses epileptiform-like
activity in an inflammation-primed human iPSC-derived neuron model of
drug-resistant epilepsy
Running title : P2X7R antagonism reduces epileptiform-like
activity in human iPSC neurons
Authors: Jaideep Kesavan1,2, Klaus
Dinkel3, Michael Hamacher4, Jochen
H. M. Prehn1,2, David C. Henshall1,2and Tobias Engel1,2*
Affiliations :
1 Department of Physiology & Medical Physics, RCSI
University of Medicine & Health Sciences, Dublin, D02 YN77, Ireland
2 FutureNeuro, SFI Research Centre for Chronic
and Rare Neurological Diseases , RCSI University of Medicine and Health
Sciences, Dublin, D02 YN77, Ireland
3 Lead Discovery Center GmbH, Otto-Hahn-Straße 15,
44227 Dortmund, Germany
4 Affectis Pharmaceuticals AG, Otto-Hahn-Straße 15,
44227 Dortmund, Germany
*Correspondence: Tobias Engel, Ph.D., Department of
Physiology & Medical Physics, RCSI University of Medicine & Health
Sciences, Dublin, D02 YN77, Ireland
Tel: +35314025199, Fax: +35314022447, Email:tengel@rcsi.ie
Manuscript details: Page numbers: 33; Figure numbers: 5;
Tables: 2; Abstract: 250 words, Introduction: 620 words; Results: 2283;
Discussion: 885 words; References: 52