Background and Purpose
Neuroinflammation is increasingly recognized to contribute to drug-resistant epilepsy. Activation of the ATP-gated P2X7 receptor (P2X7R) has emerged as an important upstream mechanism and increased P2X7R expression is present in the seizure focus in rodent models and patients. Pharmacologic antagonism of the P2X7R can attenuate seizures in rodents but this has not been explored in human neuronal networks.