not-yet-known not-yet-known not-yet-known unknown Conceptualization, J.K. and T.E.; methodology, J.K.; formal analysis, J.K.; investigation, J.K.; resources, J.K., K.D., M.H., JHM.P., DC.H. and T.E.; writing - original draft preparation, J.K., T.E.; writing - review and editing, J J.K., K.D., M.H., JHM.P., DC.H. and T.E.; supervision, T.E.; project administration, T.E.; funding acquisition, J.K., K.D., M.H., JHM.P., DC.H. and T.E. All authors have read and agreed to the published version of the manuscript. 0.1 DECLARATION OF TRANSPARENCY AND SCIENTIFIC RIGOUR Declaration of transparency and scientific rigour This Declaration acknowledges that this paper adheres to the principles for transparent reporting and scientific rigour of preclinical research as stated in the BJP guidelines for Natural Products Research, Design and Analysis, Immunoblotting and Immunochemistry, and Animal Experimentation, and as recommended by funding agencies, publishers and other organisations engaged with supporting research. 0.1 DECLARATION OF TRANSPARENCY AND SCIENTIFIC RIGOUR