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Automated Activity Monitors for Objective Monitoring of Influenza Infected Mice During Vaccine Studies
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  • Julie Zimmermann,
  • Ramona Trebbien,
  • Rebecca Jane Cox,
  • Gabriel Pedesersen
Julie Zimmermann
Statens Serum Institut

Corresponding Author:juzi@ssi.dk

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Ramona Trebbien
Statens Serum Institut Virus og Mikrobiologisk Specialdiagnostik
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Rebecca Jane Cox
Universitetet i Bergen
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Gabriel Pedesersen
Statens Serum Institut
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Abstract

Influenza viruses continue to cause severe morbidity and remain a continuous pandemic threat. Virus challenge studies in animal models are performed during preclinical vaccine development. Improved methods are needed to improve data quality in animal models to reduce both animal stress and the animal numbers. By evaluating automated activity monitors as a tool for Influenza vaccine development, we demonstrate that activity in mice declines after viral challenge and that this reduction in activity can be prevented by vaccination. Notably, the decline in activity precedes weight loss and could thus provide an objective and early endpoint in Influenza virus challenge studies.
20 Aug 2024Submitted to Influenza and other respiratory viruses
21 Aug 2024Submission Checks Completed
21 Aug 2024Assigned to Editor
06 Sep 2024Reviewer(s) Assigned
02 Oct 2024Review(s) Completed, Editorial Evaluation Pending
12 Oct 2024Editorial Decision: Revise Major
25 Nov 20241st Revision Received
27 Nov 2024Submission Checks Completed
27 Nov 2024Assigned to Editor
03 Dec 2024Reviewer(s) Assigned