We developed a temperature-switchable intermolecular dearomative [5+1] spiroannulation and [5+2] cyclization of indoles with enynones, smoothly delivering a variety of spiroindolenines and dihydrocyclohepta[b]indolones under 40 oC and 80 oC, respectively. Moreover, a well-ordered three-step cascade was realized by using the OTBS or NHBoc contained enynones in the reaction with the indole under the identical condition, a novel kind of valuable highly-oriented three-dimensional indole-based tetracyclic scaffold was produced in good yields with excellent diastereoselectivities. Additionally, various spiroindolines and spirooxindoles were facilely produced via simple operations. This highly efficient and switchable domino reaction represents an emblematic method for the prep-aration of indole-based polycycles via the intermolecular pathway.