Polymyxin-B induced skin hyperpigmentation is an adverse event which can be easily missed by physician or dermatologists due to its rarity or not knowing about the fact. Here, I'm reporting a case in an adult patient admitted for pneumonia due to multidrug resistant klebsiella, received polymyxin-B for 4 days which led to development of skin hyperpigmentation, rapid in onset, confined to face and didn't resolve in 2 months of follow up, after stoppage of the culprit drug.