This paper tackles the challenge of designing a memory-dynamic event-triggered output feedback controller for cyber-physical systems (CPSs) under distributed denial of service (DDoS) attacks. First, we consider the impact of hybrid time delays on communication networks and focus on DDoS attacks that can continuously paralyze network. Second, with limited bandwidth communication resources, a memory-dynamic event-triggered scheme (MDETS) that efficiently utilizes the bandwidth resources as well as mitigates the network-induced phenomena is proposed. In addition, to ensure the safe operation of CPSs, an output feedback controller with memory is designed based on time delay states in the measurement channel. Then, selecting the proper multi-area Lyapunov-Krasovskii functionals (LKFs), criteria for sufficient exponentially mean-square H ∞ stability condition is formulated. Finally, an illustrative example is used to demonstrate the effectiveness and applicability of the designed strategies.