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Exploring the Interplay between Cervicovaginal Microbiome, HPV Infection, and Cervical Intraepithelial Neoplasia in Taiwanese Women
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  • Chung-Yao Yang,
  • Ting-Chang Chang,
  • Yi-Tzu Lee,
  • Ting-Ying Shih,
  • Chang-Wei Li,
  • Chao-Min Cheng
Chung-Yao Yang
Hygeia Touch Inc
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Ting-Chang Chang
Chang Gung Memorial Hospital Linkou
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Yi-Tzu Lee
Taipei Veterans General Hospital
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Ting-Ying Shih
AllBio Life Incorporation
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Chang-Wei Li
AllBio Life Incorporation
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Chao-Min Cheng
National Tsing Hua University

Corresponding Author:chaomin@mx.nthu.edu.tw

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Abstract

Human papillomavirus infection is a prevalent viral condition affecting the female reproductive system, with high-risk HPV (hrHPV) posing significant risks. The vaginal microbiome plays a crucial role in the progression of cervical intraepithelial neoplasia (CIN). This study investigates the correlation between cervicovaginal microbiota and HPV status in cervicovaginal samples collected from 173 randomly selected participants enrolled in a clinical trial assessing self-sampling for HPV typing. Employing linear discriminant analysis effect size and receiver operating characteristic methodologies, microbial diversity across different cervical lesion categories was examined, identifying potential bacterial species as markers for cervical abnormalities. Among the cases analyzed, the positive predictive value of HPV infection was 74.2%, with Fannyhessea vaginae showing a relative abundance exceeding 0.00123%. This research also investigated the relationship between HPV alpha 7 and alpha 9 and various bacterial species. The findings indicated a potential association between HPV alpha 7 and Streptococcus, particularly Streptococcus pyogenes. Further observational studies are warranted to establish the association between vaginal microbiota dysbiosis and the carcinogenic potential of (hr)HPV-induced cervical cancer. The proposed microbiological biomarkers hold promise for reducing unnecessary invasive procedures and facilitating CIN risk assessment.
01 Aug 2024Submitted to Journal of Medical Virology
01 Aug 2024Submission Checks Completed
01 Aug 2024Assigned to Editor
01 Aug 2024Review(s) Completed, Editorial Evaluation Pending
02 Aug 2024Reviewer(s) Assigned
25 Sep 2024Editorial Decision: Revise Major
04 Nov 20241st Revision Received
05 Nov 2024Submission Checks Completed
05 Nov 2024Assigned to Editor
05 Nov 2024Review(s) Completed, Editorial Evaluation Pending
05 Nov 2024Reviewer(s) Assigned