Microneedle Technology in Analgesic Therapy
- Jie Jiao,
- Ze Qiang Zhao,
- Yu Ting He,
- Bin Bin Yu,
- Kejun Chen,
- Youchen Xia,
- Ruixing Yu,
- Bo Zhi Chen,
- Xin Dong Guo
Xin Dong Guo
Beijing University of Chemical Technology
Corresponding Author:xdguo@buct.edu.cn
Author ProfileAbstract
Pain management has become a prominent global health concern, affecting
not only over the aspects of daily existence but also upon the holistic
physical well-being. Conventional pain mitigation methods have
non-negligible limitations, such as the discomfort caused by needle
injections and the low permeability of transdermal drug patches due to
the skin barriers. Microneedle-based drug delivery is an emerging
technique that utilizes microscopic needles to directly administer
medication into the epidermis or dermis, offering the advantages of
enhanced efficiency, rapid action, and minimally invasive delivery.
Regarding to the analgesic therapy, microneedles are at the forefront,
accelerating pain relief by localized delivery of analgesic substances
directly to the site of discomfort. The targeted administration
effectively reduces the broader dispersion of pharmacological agents
within the circulatory system, thereby minimizing the occurrence of
systemic adverse effects. This review focuses on the utilization of
microneedle technology for both immediate and extended pain relief, its
performance in clinical practice, and the prospects and challenges of
microneedles in pain management therapy.