loading page

SYSTEMIC PHOTOBIOMODULATION: AN INTEGRATIVE REVIEW OF EVIDENCE FOR INTRAVASCULAR LASER IRRADIATION OF BLOOD AND VASCULAR PHOTOBIOMODULATION
  • +5
  • Patrícia Brassolatti,
  • Nivaldo Parizotto,
  • Elaine Caldeira de Oliveira Guirro,
  • Leandro Augusto de Almeida,
  • Carla Roberta Tim,
  • Michele Akemi Nishioka,
  • José Ricardo de Souza,
  • Ana Laura de Andrade
Patrícia Brassolatti
Department of Research Development and Innovation at Brazilian medical equipment industry - Ibramed
Author Profile
Nivaldo Parizotto
Universidade Brasil
Author Profile
Elaine Caldeira de Oliveira Guirro
Universidade de Sao Paulo - Campus de Ribeirao Preto
Author Profile
Leandro Augusto de Almeida
Universidade Brasil
Author Profile
Carla Roberta Tim
Universidade Brasil
Author Profile
Michele Akemi Nishioka
Department of Research Development and Innovation at Brazilian medical equipment industry - Ibramed
Author Profile
José Ricardo de Souza
Ibramed Company – Brazilian medical equipment industry
Author Profile
Ana Laura de Andrade
Universidade Brasil

Corresponding Author:anandrade90@yahoo.com.br

Author Profile

Abstract

Currently, an increasing number of studies about systemic laser photobiomodulation (FBM), have been highlighted in the literature; however, they differ in their application methods, which can be intravenous (intravascular laser irradiation of blood), or transdermally, (vascular photobiomodulation). This review aimed to compile all findings on these techniques and critically discuss their results. A search for articles was conducted in the PubMed, Scopus, and Web of Science databases. After applying inclusion and exclusion criteria, 37 articles were selected. Of these, 19 studies discussed the use of systemic FBM with intravenous application, and 7 studies reported transcutaneous application. Regarding clinical studies, 28 studies addressed the application of the techniques in respiratory, cardiovascular, metabolic, neurological, and musculoskeletal conditions. For preclinical studies, 9 articles primarily discussed the application in pulmonary and musculoskeletal conditions. Despite the promising results, methodological limitations and variabilities in studies on systemic laser FBM prevent the categorical assertion of its efficacy.