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Genetic evolution between HIV-1 groups M and O: HIV-1/MO recombinant forms
  • Moisan Alice,
  • Fabienne Tombette,
  • Jean-Christophe Plantier
Moisan Alice
Centre Hospitalier Universitaire de Rouen

Corresponding Author:alice.moisan@chu-rouen.fr

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Fabienne Tombette
Centre Hospitalier Universitaire de Rouen
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Jean-Christophe Plantier
Centre Hospitalier Universitaire de Rouen
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Abstract

HIV exhibits significant genetic diversity, with genetic recombination being a major evolutionary process. The co-circulation of HIV-1/M and HIV-1/O variants has led to the description of 20 HIV-1/M+O dual infections since 1998. Despite the genetic divergence between these variants, HIV-1/M+O dual infections have resulted in the emergence of HIV-1/MO intergroup recombinant forms, with 20 unique HIV-1/MO recombinant forms (URF_MO) currently described, raising the question of a possible benefit of the recombination and the modalities of their emergence.. This review summarized the current knowledge on HIV-1/MO recombinant forms, including their virological and genetic characteristics, phylogenetic analysis, genome profiles, and breakpoints number and location. This work also identified the potential impacts of HIV-1/MO recombination on diagnosis, monitoring, and treatment, as well as the replicative capacity of such recombinants. This review highlighted the greater diversity and complexity of HIV-1/MO recombinants than originally thought, offering new research perspectives on their emergence and virological properties.
24 Jul 2024Submitted to Journal of Medical Virology
25 Jul 2024Submission Checks Completed
25 Jul 2024Assigned to Editor
25 Jul 2024Review(s) Completed, Editorial Evaluation Pending
26 Jul 2024Reviewer(s) Assigned
11 Sep 2024Editorial Decision: Revise Major