Objectives: The purpose of this study was to look into the efficacy of caffeic acid phenethyl ester (CAPE), which we believe may be therapeutically useful in facial nerve restoration due to its neuroprotective and antioxidant properties. Materials and Methods: 20 Sprague Dawley rats were divided randomly into 4 primary and 2 secondary groups and assigned as control, methylprednisolone, CAPE, CAPE+methylprednisolone groups and the sham and the trauma groups. Except for the sham group, all groups had the left facial nerve crushed. Three weeks after surgery, prospective functional, electrophysiologic, and histologic recovery was assessed. Results: The CAPE and CAPE+ methylprednisolone group had similar and more significant recovery at Nerve Excitability Thresholds at the end of three weeks. In histopathological evaluation, when the groups were compared in terms of myelin sheath thickness, vascular congestion and axonal degeneration, it was observed that only the CAPE+ methylprednisolone group achieved a significantly faster improvement compared to the control group. Although there was an earlier improvement in the blink tests in the CAPE and CAPE+steroid group compared to the methylprednisolone and control groups, complete recovery was observed in all groups on the 21st day. Conclusion: The combination of caffeic acid phenethyl ester and methylprednisolone was found to be efficient in nerve regeneration and may be a good alternative for lowering the dose of methylprednisolone to minimize adverse effects. Key Words: Caffeic acid phenetyl ester, facial nerve, neuroprotective agents, experimental rat model.