Objectives In laryngopharyngeal reflux (LPR) gold standard in diagnostics is still lacking. A proton pump (PPI) trial is often completed but the effect and diagnostic accuracy in LPR is disputed and not only acid refluxes are considered having impact in LPR. Therefor further diagnostic evaluations may be needed. Earlier, 24h pH-measuring including a proximal probe was most often performed, but combined 24h pH-impedance monitoring (24h pH-MII) is now considered superior to the traditional method. The main aim of this study is to investigate if we find more persons with pre-conditions of LPR evaluated by 24h-pH-MII compared to conventional 24h-pH measuring including a high probe. Design Retrospectively, we included 24h pH-MII measurements performed December 2016 - December 2019 concerning LPR as the issue of question. In total 82 measurements were included and analyzed. The measuring was considered positive if at least one proximal regurgitation occurred during the 24h. Results Based on the 24h pH-measurings, 38% of the subjects had ≥1 proximal regurgitation, compared to 98% in the 24h pH-MII measuring. This results in percent agreement of 39.5% Negative proximal impedance was found in only one subject. This could possibly be due to a too low limit for considering the measurement positive. LPR is on the other hand, according to the available epidemiological data, common and possibly only the most severe cases get referrals for further diagnostic evaluations. Conclusion The present study gives further evidence of 24h pH-MII being superior to conventional 24h pH-measuring in LPR diagnostics.