loading page

Layer-specific connectivity and functional impact of Chrna2+ layer 5 Martinotti cells in the primary motor cortex
  • +3
  • Anna Velica,
  • Katharina Henriksson,
  • Thawann Malfatti,
  • Ingrid Nogueira,
  • Evridiki Asimakidou,
  • Klas Kullander
Anna Velica
Uppsala University
Author Profile
Katharina Henriksson
Uppsala University
Author Profile
Thawann Malfatti
Uppsala University
Author Profile
Ingrid Nogueira
Uppsala University
Author Profile
Evridiki Asimakidou
Uppsala University
Author Profile
Klas Kullander
Uppsala University

Corresponding Author:klas.kullander@neuro.uu.se

Author Profile

Abstract

The cortical somatostatin interneuron population includes several diverse cell types, among them the Martinotti cells. Layer-specific differences in connectivity and function between different subtypes of Martinotti cells are becoming apparent, which require contemporary studies to investigate cortical interneurons in a layer and subtype specific manner. In this study, we investigate the connectivity of a subtype of Chrna2+ layer 5 Martinotti cells in the primary motor cortex, using a monosynaptic retrograde rabies viral tracer. We found direct input from pyramidal cells and local parvalbumin interneurons. In addition, we found long-range direct inputs from the motor thalamus, substantia innominata of the basal forebrain and globus pallidus. Based on the observed input pattern, we tested and found an increased number of falls in the hanging wire test upon temporary overexcitation of Chrna2+ layer 5 Martinotti cells. These results suggest that Chrna2+ Martinotti cells in the motor cortex are involved in sensorimotor integration.
17 Jul 2024Submitted to European Journal of Neuroscience
21 Jul 2024Submission Checks Completed
21 Jul 2024Assigned to Editor
21 Jul 2024Review(s) Completed, Editorial Evaluation Pending
01 Aug 2024Reviewer(s) Assigned
27 Aug 2024Editorial Decision: Revise Major
06 Nov 20241st Revision Received