The main antigens in the Rh blood group system are D, C, c, E and e 1. D– is a rare type that lacks C,c,E,e antigens, elevating D on RBC surface 2. Alloimmunization to anti-Rh17 causes severe HDFN 4. We report a case of Rh17 alloimmunization, treated with incompatible blood. Prenatal therapies included plasma exchange, intravenous immunoglobulin (IVIG) and intrauterine transfusions (IUTs). The infant, delivered at 32 weeks, experienced hyperbilirubinemia and anemia, managed with transfusions and medications. Due to the rarity of the condition, finding compatible blood is challenging, necessitating management with incompatible blood in severe HDFN cases, as exemplified in our case.