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Enantioselective Total Synthesis of (+)-Propolisbenzofuran B
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  • Wen-Xiu Xu,
  • Li-Han Zhao,
  • Yao Zhu,
  • Hai-Hua Lu
Wen-Xiu Xu
Zhejiang University
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Li-Han Zhao
Westlake University
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Yao Zhu
Westlake University
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Hai-Hua Lu
Westlake University

Corresponding Author:luhaihua@westlake.edu.cn

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Abstract

The first catalytic asymmetric total synthesis of (+)-propolisbenzofuran B, enabled by a highly enantioselective rhodium-catalyzed hy-drogenation of a tetrasubstituted olefin, was described. Other noteworthy aspects include the construction of the central hydrodiben-zo[b,d]furan core through a sequence of Zn(II)-mediated regioselective benzofuran formation and Dieckmann condensation, as well as C-H oxidations, involving a visible light-induced Fe(III)-catalyzed benzylic C(sp3)-H oxidation. Additionally, the absolute configuration was confirmed by X-ray analysis of a carbonate intermediate.
28 May 2024Submitted to Chinese Journal of Chemistry
29 May 2024Review(s) Completed, Editorial Evaluation Pending
30 May 2024Reviewer(s) Assigned
13 Jun 20241st Revision Received
19 Jun 2024Submission Checks Completed
19 Jun 2024Assigned to Editor
19 Jun 2024Review(s) Completed, Editorial Evaluation Pending
27 Jun 2024Editorial Decision: Accept