not-yet-known not-yet-known not-yet-known unknown Kainic Acid-Induced Temporal Lobe Epilepsy Animal Model Sprague-Dawley male rats (7 week-old) were randomly assigned for TLE-induced model or for control. Status epilepticus (SE) was induced by intraperitoneal (i.p.) injection of 10 mg/kg kainic acid (KA, Tocris, Bristol, England) (Sakurai et al., 2018) solubilized in saline (0.9% NaCl). The other group of animals was injected with saline at the same time and registered as the control group. The animals from the same cage were separated the day before SE induction, being housed as 2 animals per cage. The animals were observed directly and monitored with two cameras: Go pro 4K and ELP night vision infrared fisheye lens wide angle waterproof dome, along with a USB webcam (Model ELP-USBFHD05MT-DL170), positioned appropriately on either side of the cage. This allowed for further assessment of the seizure severity following KA injection. The modified Racine Scale was adopted to characterize the seizures: stage 1, facial clonus; stage 2, nodding and wet dog shaking; stage 3, unilateral forelimb clonus with lordotic posture; stage 4, lateral forelimb clonus with rearing, and stage 5, bilateral forelimb clonus with falling (Racine, 1972; Reddy & Kuruba, 2013). When stage 5 lasted for more than 5 minutes, animals were sacrificed with a lethal dose (1-2 mL) of pentobarbital (Euthasol® 400 mg/mL, Dechra, Northwick, England) (humane endpoint). Following SE, the animals were reintroduced alongside their initial cage co-inhabitants and supervised closely for the appearance of distress symptoms. Four weeks after SE induction, animals were monitored for the appearance of spontaneous recurrent convulsive seizures. From this timepoint period on, animals were considered to have established epilepsy (EE). The animals were then euthanized with isoflurane (Isoflurin® 1000 mg/g, Hifarmax) and their hippocampal slices were used in field excitatory postsynaptic potential (fEPSP) recordings. Control animals were similarly housed and grouped.