not-yet-known not-yet-known not-yet-known unknown Selective modulation of epileptic tissue by an adenosine A3 receptor-activating drug Anwesha Ghosh1,2*, Leonor Ribeiro-Rodrigues1,2*, Gabriele Ruffolo3,4, Veronica Alfano4, Cátia Domingos1,2†, Nádia Rei1,2‡, Dilip K. Tosh5, Diogo M Rombo1,2, Tatiana P. Morais6,7, Cláudia A. Valente1,2, Sara Xapelli1,2, Beatriz Bordadágua8,9,10, Alexandre Rainha-Campos11,12, Carla Bentes11,13,14, Eleonora Aronica15,16, Maria José Diógenes1,2, Sandra H. Vaz1,2, Joaquim A. Ribeiro1,2, Eleonora Palma3, Kenneth A. Jacobson5, Ana M. Sebastião1,2a 1Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; 2Instituto de Medicina Molecular João Lobo Antunes, Universidade de Lisboa, Lisboa, Portugal; 3Department of Physiology and Pharmacology, University of Rome Sapienza, Rome, Italy; 4IRCCS San Raffaele Roma, 00166, Rome, Italy; 5Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA; 6Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK; 7Department of Physiology and Biochemistry, University of Malta, Msida MSD 2080, Malta; 8Heidelberg Institute for Theoretical Studies (HITS), Heidelberg, Germany. 9Heidelberg University, Heidelberg, Germany. 10Instituto Superior Técnico - Universidade de Lisboa, Lisboa, Portugal; 11Centro de Referência para a área da Epilepsia Refratária (ERN EpiCARE member), CHULN; 12Serviço de Neurologia, CHULN; 13Laboratório de EEG/Sono - Unidade de Monitorização Neurofisiológica, Serviço de Neurologia, CHULN; 14Centro de Estudos Egas Moniz. Faculdade de Medicina da Universidade de Lisboa; 15Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Department of (Neuro)Pathology, Amsterdam, The Netherlands; 16Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, The Netherlands