Background and Purpose
Adenosine, through the A1 receptor
(A1R), is an endogenous anticonvulsant. Development of
adenosine receptor agonists as antiseizure medications has been hampered
by their cardiac side effects. A moderately
A1R-selective agonist, MRS5474, has been reported to
suppress seizures without considerable cardiac action. Hypothesizing
that this drug could act through other than A1R and/or
through a disease specific mechanism, we assessed the effect of MRS5474
on the hippocampus.