Enhancing the reliability-accuracy tradeoff for Global Navigation Satellite System (GNSS) applications is exponentially important, especially in dealing with the negative effects caused by ionospheric disturbances. This research seeks to put hands-on betterment of GNSS Radio Occultation (GNSS-RO), which is suggested by improving the prediction of the ionospheric Vertical Total Electron Content (VTEC) worst-case scenarios. On the other hand, it is aspired to align with the recent data assimilation and satellite remote sensing approaches. This work focuses on optimizing ionospheric VTEC using the NeQuickG model, driven by Galileo satellite coefficients. NeQuickG, a global ionospheric model that is developed by both the International Center for Theoretical Physics (ICTP) and the University of Graz, provides better spatial and temporal resolution. This work applies Particle Swarm Optimization (PSO) to identify the latitude, longitude, and time of day at which VTEC peaks, which represents the worst-case scenarios for GNSS performance, and hence, addresses such impacts of high VTEC values. This proposed approach utilizes the most available Galileo coefficients from NASA's Archive of Space Geodesy Data (CDDIS), dating back to both 2019 and 2017. As a yield, the proposed optimization process pinpoints the geographical grid that has the highest VTEC values at latitude \(-9.8^o\) and longitude \(-8.8^o\). Compared to other randomly picked grids, the proposed optimization shows an absolute maximum VTEC at all altitudes. Interestingly, the simulated VTEC peak, at Earth altitude of \(300\) kms, shows an order-of-magnitude convergence with that VTEC at a Mars radial distance of \(3500\) kms, which motivates a further planetary and terrestrial comparative analysis approach. Furthermore, the optimized simulated peak VTEC converges with that reported using the Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) satellite data, amid geomagnetic storms in the Mid-Atlantic Ocean, near Saint Helena, Ascension and Tristan da Cunha. In summary, this research put hands-on combining the bio-inspired optimization algorithms with the mathematical parameter-based (Galileo) ionospheric model as NeQuickG. Consequently, in order to improve GNSS-RO data assimilation and signal integrity, more precise forecasting of spatial and temporal VTEC maxima may be possible with the NeQuickG-driven PSO optimization as described in this work. It is hoped that this operational insight can be useful for supporting these immune, space-based navigation and weather services, as well as for furtherly developing atmospheric sounding based on nanosatellites and CubeSats. Further, it is hugely aspired to even beat a harmony with the larger endeavors that enhance GNSS reliability under the dynamic ionospheric variability nature, which in turn resonates with the atmospheric and space weather research community.AcknowledgmentsSpecial thanks to Prof. Nathaniel A. Frissell (W2NAF) - the Ham Radio Science Citizen Investigation (HamSCI) lead; Mr. Gary Mikitin (AF8A) - Radio Operators Expert; and Mr. Bill Liles (NQ6Z) - HamSCI Community (Diversity Recruitment Chair), in collaboration with the University of Scranton. Special thanks for the financial support of the U.S. National Science Foundation Grant AGS-2404997 and Amateur Radio Digital Communications (ARDC). Special thanks to my Dream NASA Space Apps team: Marcin Leśniowski, Dr. Pasumarthi Babu Sree Harsha, Matt Downs, Daniel Metcalfé, and Sıla Kardelen Karabulut.