not-yet-known not-yet-known not-yet-known unknown Raptors, with their specialized adaptations, often target a diverse array of prey, frequently including primates, but their primary predation tends to focus on non-anthropoid species. We report a case of harpy eagle Harpia harpyja, one of the Earth’s largest eagle, attack on adult human beings, in French Guiana, in the Amazon rainforest. We analyze the raptor’s aggression patterns and the incidents’ context. We examined both published and unpublished records of raptors attacking anthropoids—including humans—offering a comprehensive single-reference into these rare interactions.