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The LOng-Term Follow-up TIPP project: LOFT study protocol, a 20-year prospective study of early psychosis patients
  • +10
  • Teya Petrova,
  • Philippe Golay,
  • Paul Klauser,
  • Sandra Vieira,
  • Inès Lepreux,
  • Boshra H. Razavi,
  • Raoul Jenni,
  • Nadir Mebdouhi,
  • Martine Cleusix,
  • Caroline Conchon,
  • Lilith Abrahamyan Empson,
  • Philippe Conus,
  • Luis Alameda
Teya Petrova
Centre Hospitalier Universitaire Vaudois

Corresponding Author:teya.petrova@chuv.ch

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Philippe Golay
Centre Hospitalier Universitaire Vaudois
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Paul Klauser
Centre Hospitalier Universitaire Vaudois
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Sandra Vieira
Centre Hospitalier Universitaire Vaudois
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Inès Lepreux
Centre Hospitalier Universitaire Vaudois
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Boshra H. Razavi
Centre Hospitalier Universitaire Vaudois
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Raoul Jenni
Centre Hospitalier Universitaire Vaudois
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Nadir Mebdouhi
Centre Hospitalier Universitaire Vaudois
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Martine Cleusix
Centre Hospitalier Universitaire Vaudois
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Caroline Conchon
Centre Hospitalier Universitaire Vaudois
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Lilith Abrahamyan Empson
Centre Hospitalier Universitaire Vaudois
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Philippe Conus
Centre Hospitalier Universitaire Vaudois
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Luis Alameda
Centre Hospitalier Universitaire Vaudois
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Abstract

Introduction: Early intervention Services (EIS) in psychosis are the gold standard to treat patients after a first episode of psychosis (FEP). However, the understanding of the evolution and the long-term effects of such type of intervention is limited. This study aims to gain insight into the long-term evolution of physical and mental health, as well as the neurobiological outcomes of the patients treated for a FEP. Methods: The Long-term Follow-up of TIPP (LOFT) is an up to 20-year study within a cohort of patients who completed a three-year EI treatment at Treatment and early Intervention in Psychosis Program (TIPP, in Lausanne, Switzerland) and went through a deep phenotyping prospective multimodal assessment. 720 patients will be contacted and asked to participate in LOFT. Once they are assessed they will be allocated to a timepoint at either 5(+2), 10(±2), 15(±2), and 20(-2) years after TIPP entry. A follow-up visit will be proposed every 5 years. All participants will be evaluated on psychopathological, functional, and physical health outcomes including metabolic disturbances. A subsample of the patients who previously took part in a biomarker research program (n = 168) whilst at TIPP will be invited to undergo additional assessments (cognition, brain imaging, biofluids collection). Both traditional group level and machine learning analyses will be conducted. Conclusion: Ethical approval has been obtained and recruitment started in 2024. LOFT will help reshape and redefine current interventions for subgroups of patients at risk of poorer long-term outcome and to understand the underlying neurobiological mechanisms influencing psychosis evolution.
04 Jun 2024Submitted to Early Intervention in Psychiatry
06 Jun 2024Submission Checks Completed
06 Jun 2024Assigned to Editor
06 Jun 2024Review(s) Completed, Editorial Evaluation Pending
26 Jun 2024Reviewer(s) Assigned