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Early-pregnancy BMI, Maternal Gestational Weight Gain, and Asthma and Allergic Diseases in Children.
  • +11
  • Vincent Ojwang,
  • Bright Nwaru,
  • Hanna-Mari Takkinen,
  • Heli Tapanainen,
  • Minna Kaila,
  • Suvi Ahonen,
  • Onni Niemelä,
  • Anna-Maija Haapala,
  • Jorma Ilonen,
  • Jorma Toppari,
  • Heikki Hyöty,
  • Riitta Veijola,
  • Mikael Knip,
  • Suvi M. Virtanen
Vincent Ojwang
Tampereen yliopisto

Corresponding Author:vincent.ojwang@yahoo.com

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Bright Nwaru
Tampereen yliopisto
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Hanna-Mari Takkinen
Tampereen yliopisto
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Heli Tapanainen
Terveyden ja hyvinvoinnin laitos Kansanterveysratkaisut
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Minna Kaila
Sairaala Mehilainen Tampere
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Suvi Ahonen
Tampereen yliopisto
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Onni Niemelä
Tampereen yliopisto
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Anna-Maija Haapala
Fimlab Laboratoriot Oy
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Jorma Ilonen
Turun yliopisto Genetiikan laboratorio
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Jorma Toppari
Turun yliopisto
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Heikki Hyöty
Tampereen yliopisto
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Riitta Veijola
Medical Research Center Oulu
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Mikael Knip
Sairaala Mehilainen Tampere
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Suvi M. Virtanen
Tampereen yliopisto
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Abstract

Background: Association of early pregnancy body mass index (BMI) and maternal gestational weight gain (GWG), and asthma and allergic disease in children is unclear. Methods: We analyzed data from 3,176 mother-child pairs in a prospective birth cohort study. Maternal anthropometric measurements in the first and last antenatal clinic visits were obtained through post-delivery questionnaires to calculate early pregnancy BMI and maternal GWG. Asthma and allergic diseases in children by the age of 5 years was assessed using a validated questionnaire. Furthermore, serum samples were analyzed for IgE antibodies to eight allergens. We applied Cox proportional hazards and logistic regression analyses to estimate the association of early pregnancy BMI and maternal GWG (as continuous variables and categorized into quarters), and asthma, atopic eczema, atopic sensitization, and allergic rhinitis in children. Results: Early pregnancy BMI and maternal GWG were not associated with asthma and allergic disease in children when analyzed as continuous variables. Compared to the first quarter (GWG <0.32 kg/week), mothers in the third quarter (GWG 0.42-0.52 kg/week) had children with higher odds of developing atopic eczema (adjusted OR 1.49, 95% CI [1.13-1.96]) by age 5 years. Conclusion: The association of early pregnancy BMI and maternal GWG and asthma and allergic disease in children is inconsistent. High maternal GWG may be associated with increased odds of atopic eczema.
04 Jun 2024Submitted to Pediatric Allergy and Immunology
06 Jun 2024Submission Checks Completed
06 Jun 2024Assigned to Editor
06 Jun 2024Review(s) Completed, Editorial Evaluation Pending
07 Jun 2024Reviewer(s) Assigned
27 Aug 20241st Revision Received
28 Aug 2024Submission Checks Completed
28 Aug 2024Assigned to Editor
28 Aug 2024Review(s) Completed, Editorial Evaluation Pending
29 Aug 2024Editorial Decision: Accept