Objectives. To estimate postpartum depression at two months (PPD) prevalence and its related risk factors. Design. Multicentre prospective cohort study. Setting. France. Population or sample. Representative sample of 7,133 women participating to the French National Perinatal Survey (ENP) over one week in March 2021. Methods. Data on maternal characteristics, course of pregnancy/delivery, and child’s health were collected from face-to-face interviews in maternity wards and/or medical records, and a self-questionnaire (including the Edinburgh Postnatal Depression Scale (EPDS)) at two months postpartum. Women with an EPDS score >=13 were considered to have PPD. Poisson regression models with robust variance were used to estimate adjusted prevalence ratios (aPR) for PPD. Main Outcome Measures. PPD Results. PPD prevalence at two months was 16.7% (95%CI[15.7-17.7]). Factors significantly associated with PPD were: i/ age<=29 or >=40 years (maximum aPR=1.41 95%CI[1.12-1.77] obtained for 15-24 year-olds vs 35-39 year-olds), ii/ being born in North Africa (1.29[1.02-1.64] vs France), iii/ having a lower level of health literacy (1.23[1.14-1.35]), iv/ having a history of psychological (1.45[1.24-1.69]) or psychiatric (1.52[1.23-1.88]) care since adolescence (vs none), v/ receiving little/no support or good support during pregnancy (1.80[1.52-2.14] and 1.31[1.15-1.48] vs. receiving very good support), vi/ reporting feelings of sadness (1.92[1.65-2.25]), anhedonia (1.69[1.36-2.11]) or both (2.61[2.26-3.01]) during pregnancy (vs none of these feelings), vii/ having had an instrumental vaginal delivery (1.18[1.01-1.38] vs spontaneous vaginal delivery). Conclusions. Our findings on PPD (prevalence and risk factors) could guide policies on early identification and preventive support for women in the perinatal period.