Pure red cell aplasia (PRCA) is characterized by isolated anemia and a marked reduction or absence of erythroid precursors in the bone marrow. Depending on the underlying etiology, treatment may include immunomodulation or cytotoxic agents, chronic red blood cell transfusions, or hematopoietic stem cell transplantation. Parvovirus B19 infection is a well-recognized cause of transient PRCA, typically resolving with viral clearance. We report an unusual late relapse of PRCA occurring years after parvovirus B19 eradication, unresponsive to steroids and mycophenolate mofetil. Remarkably, prolonged treatment with intravenous immune globulin (IVIG) resulted in complete remission, highlighting its therapeutic utility for idiopathic PRCA.