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Principles of bacterial genome organization, a conformational point of view
  • +2
  • Sokrich Ponndara,
  • Mounia Kortebi,
  • Frédéric Boccard,
  • Stéphanie Bury-Moné,
  • Virginia Lioy
Sokrich Ponndara
Institut de Biologie Integrative de la Cellule
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Mounia Kortebi
Institut de Biologie Integrative de la Cellule
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Frédéric Boccard
Institut de Biologie Integrative de la Cellule
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Stéphanie Bury-Moné
Institut de Biologie Integrative de la Cellule
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Virginia Lioy
Institut de Biologie Integrative de la Cellule

Corresponding Author:virginia.lioy@i2bc.paris-saclay.fr

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Abstract

In bacteria, the chromosome is folded into a structure called the nucleoid. This compaction must facilitate and maintain key biological processes such as gene expression and DNA transactions (replication, recombination, repair, segregation). Chromosome and chromatin 3D-organization in bacteria has been a puzzle for decades. Chromosome conformation capture coupled to deep sequencing (HiC) in combination with other ‘omics’ approaches has allowed dissection of the structural layers that shape bacterial chromosome organization, from DNA topology to global chromosome architecture. Here we review the latest findings in the field and discuss the main features of bacterial genome folding.
15 Apr 2024Submitted to Molecular Microbiology
16 Apr 2024Submission Checks Completed
16 Apr 2024Assigned to Editor
08 May 2024Review(s) Completed, Editorial Evaluation Pending
08 May 2024Editorial Decision: Revise Minor
03 Jun 20241st Revision Received
05 Jun 2024Submission Checks Completed
05 Jun 2024Assigned to Editor
05 Jun 2024Reviewer(s) Assigned
06 Jun 2024Review(s) Completed, Editorial Evaluation Pending
06 Jun 2024Editorial Decision: Accept