Introduction
Chorioangioma is a benign vascular tumor of the placenta that occurs in
approximately 1% of pregnancies1. The majority of
cases are small and asymptomatic, with symptoms appearing in only
0.01%–0.03% of instances2. Giant chorioangiomas,
defined as tumors larger than 4 cm, are remarkably rare, with a
prevalence ranging from 1:9,000 to 1:50,000 3. While
many chorioangiomas are detected during postnatal examination of
placental histology, large chorioangiomas are associated with
significant maternal and fetal complications. These include preterm
labor, intrauterine growth restriction (IUGR), pre-eclampsia,
polyhydramnios as well as hydrops fetalis, disseminated intravascular
coagulation (DIC), and mortality 4–6.
Despite significant advancements in therapeutic approaches, perinatal
mortality rates remain high, estimated to be more than 30%7. Therefore, it is essential to highlight the
importance of timely identification, comprehensive prenatal monitoring,
and appropriate interventions to prevent fetal morbidity and mortality8. In this report, we present a case involving
multiple giant chorioangiomas in a 23-year-old woman, which were
associated with fetal complications and ultimately resulted in the
neonate’s death due to hydrops fetalis. This case emphasizes the
complexity of this condition and underscores the necessity for a
multidisciplinary approach in evaluating and counseling patients with
intricate fetal anomalies. This study has been reported in line with the
CARE criteria9.