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Research progress on the role of zinc finger protein in colorectal cancer
  • +5
  • Xinmei Guo,
  • TANG YU,
  • Ziwei Li,
  • Chenglong Pan,
  • Jialing Liu,
  • Kepu Zheng,
  • XiaoHao Wang,
  • Yan Zhang
Xinmei Guo
Kunming University of Science and Technology School of Life Science and Technology
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TANG YU
Yunnan Cancer Hospital
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Ziwei Li
Chongqing Health Center for Women and Children
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Chenglong Pan
First Affiliated Hospital of Kunming Medical University
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Jialing Liu
Yunnan Cancer Hospital
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Kepu Zheng
First Affiliated Hospital of Kunming Medical University Department of Oncology
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XiaoHao Wang
The Second Affiliated Hospital of Chongqing Medical University
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Yan Zhang
The Second Affiliated Hospital of Chongqing Medical University

Corresponding Author:zhangyan@hospital.cqmu.edu.cn

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Abstract

Colorectal cancer is one of the most prevalent malignancies worldwide, with a tendency of increasing incidence in developed countries, which poses a significant threats to the patients’ physical and mental health. The development of colorectal cancer involves numerous genetic alterations, which indicate that transcription factors may play an important role in this process. Changes in the level of zinc finger proteins, the most prevalent transcription factor, may play an important trigger for the development of colorectal cancer. Different zinc finger proteins play different roles in terms of promoting or inhibiting cancer development. This paper briefly reviews the classification, functional characteristics, and expression changes of zinc finger proteins in colorectal cancer, it focuses on how they regulate gene transcription, influence on common signaling pathways and their potential for translational studies and clinical applications. The objective is to stimulate new ideas for their study in colorectal cancer while also providing foundational information to guide drug development and treatment strategies for colorectal cancer patients in clinical settings.