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Differential atrophy along the longitudinal hippocampal axis in Alzheimer's disease
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  • Rafaela Morais-Ribeiro,
  • Francisco Almeida,
  • Ana Coelho,
  • Tiago Oliveira
Rafaela Morais-Ribeiro
University of Minho
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Francisco Almeida
University of Minho
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Ana Coelho
University of Minho Life and Health Sciences Research Institute
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Tiago Oliveira
Universidade do Minho

Corresponding Author:tiago@med.uminho.pt

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Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that primarily affects the hippocampus. Since hippocampal studies have highlighted a differential subregional regulation along its longitudinal axis, a more detailed analysis addressing subregional changes along the longitudinal hippocampal axis has the potential to provide new relevant biomarkers. This study included structural brain MRI data of 583 participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Cognitively normal (CN) subjects, mild cognitively impaired (MCI) subjects and AD patients were conveniently selected considering the age- and sex-match between clinical groups. Structural MRI acquisitions were pre-processed and analysed with a new longitudinal axis segmentation method, dividing the hippocampus in three subdivisions (anterior, intermediate, and posterior). When normalizing the volume of hippocampal sub-divisions to total hippocampus, the posterior hippocampus negatively correlates with age only in CN subjects (r = -0.31). The longitudinal ratio of hippocampal atrophy (anterior sub-division divided by the posterior one) shows a significant increase with age only in CN (r = 0.25). Overall, in AD the posterior hippocampus is predominantly atrophied early on. Consequently, the anterior/posterior hippocampal ratio is an AD differentiating metric at early disease stages with potential for diagnostic and prognostic applications.
31 Mar 2024Submitted to European Journal of Neuroscience
02 Apr 2024Review(s) Completed, Editorial Evaluation Pending
02 Apr 2024Reviewer(s) Assigned
03 Apr 2024Editorial Decision: Accept