This study is novel in that it quantitatively exams the impact of human brucellosis, an endemic zoonotic disease in Malta from 1919 until 1954, and the impact on reproductive loss through stillbirths. Based on regression analysis, brucellosis had a statistically significant effect (t = 2.8986, p = 0.0039) on stillbirth rate for males, but the effect of brucellosis on stillbirths is not statistically significant for females (p = 0.9103). This paper points to the importance of brucellosis, one of the most common zoonotic diseases, as having implications for health burden in women and fetuses in the contemporary context; this relationship has been largely ignored in the literature.